Curriculum
Module 08 · 30 min

MOTS-c & Mitochondrial Peptides

Mitochondrial-derived peptides — exciting biology, immature clinic.

ClinicalAdvanced
Core topics

What's covered

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Learning objectives

By the end of this module you will be able to

  • L01Place MOTS-c on the evidence map; explain why current clinic offerings are speculative.
Expected takeaways

What you should walk away believing

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Lesson · Core emphasis

What this means for you

Patient summary

MOTS-c is a small peptide encoded by mitochondrial DNA. Animal studies suggest it may improve insulin sensitivity. Human clinical evidence essentially doesn't exist yet.

Clinician summary

Counsel patients that 'mitochondrial peptide therapy' offerings are pre-evidence — the receptor target is not even fully defined.

Evidence-graded claims

What the data say

B
MOTS-c improves insulin sensitivity in mice
Replicated preclinical.
D
MOTS-c safely augments human exercise capacity
No controlled human trials.
Quick check

Test yourself

Q1MOTS-c is encoded by:
Flashcards · Spaced repetition

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What does MOTS-c stand for?
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References · 2

Sources cited in this module

  1. [1]
    The mitochondrial-derived peptide humanin and aging
    Kim SJ. et al. · Aging Cell · 2018Review · T3
  2. [2]
    The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis
    Lee C. et al. · Cell Metabolism · 2015Mechanism / preclinical · T3
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